The Use of Near Infrared Spectroscopy to Evaluate the Effect of Exercise on Peripheral Muscle Oxygenation in Patients with Lower Extremity Artery Disease: A Systematic Review

ObjectiveNear infrared spectroscopy (NIRS) has been suggested as a new diagnostic tool in patients with lower extremity artery disease (LEAD). The aim of this systematic review was to summarise the impact exercise therapy on limb muscle oxygenation, evaluated by NIRS, LEAD, and give an overview NIRS instruments methodology.Data SourcesMEDLINE Embase.Review MethodsA search conducted MEDLINE Embase, from earliest date available until 16 March 2020, identify peer reviewed studies involving use evaluation training oxygenation LEAD. Primary outcomes were derived variables during treadmill exercise. Effect sizes calculated standardised mean differences. Assessment methodological quality done using combined checklist Cochrane bias assessment for before after without control group.ResultsEleven original trials included groups four groups. Tissue saturation index (TSI) at rest remained unchanged following interventions. Exercise increased time minimum TSI (range effect sizes: +0.172 +0.927). In addition, led faster recovery half full values most intervention –0.046 –0.558 –0.269 –0.665, respectively). Finally, data reproducibility analytic methods under reported studies.ConclusionThe suggest that improves de-oxygenation re-oxygenation patterns, measured Whereas is promising low number randomised controlled trials, well large heterogeneity methods, outcome measures, instrumentation, warrants more research better understand role associated induced improvements walking capacity. Near methodology. Embase. A group. Eleven studies.